将机器学习应用于注射药物产品的视觉检查
Romain Veillon1, John Shabushnig2, Lars Aabye-Hansen3
1GSK, Wavres, Belgium.
PDA journal of pharmaceutical science and technology
|June 15, 2023
概括
机器学习 (ML) 增强了可注射药物的自动视觉检查 (AVI),改善了缺陷检测,减少了虚假拒绝. 这项技术与现有的硬件和验证流程无集成.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 计算机视觉 计算机视觉 计算机视觉
- 人工智能的人工智能是人工智能.
背景情况:
- 手动视觉检查 (MVI) 在吞吐量和一致性方面面临限制.
- 机器学习 (ML) 提供了增强自动视觉检查 (AVI) 的潜力.
研究的目的:
- 为了捕捉当前的经验,并为应用ML到注射药物产品的AVI提供考虑.
- 突出ML在药品质量控制中的好处.
主要方法:
- 将ML集成到现有的机器视觉硬件中.
- 利用人工智能工具加速配方开发和模型配置.
主要成果:
- 与传统的检查工具相比,证明了更高的缺陷检测率.
- 显示了虚假拒绝率的降低.
- 实现ML不需要对当前的AVI资格策略进行修改.
结论:
- 在制药生产中,ML技术可用于AVI应用.
- 成功的ML实施通过建立的验证策略,确保在生产环境中可靠的性能.
相关概念视频
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
105
In pharmacokinetics, the elimination rate of a drug following a capacity-limited model is primarily controlled by two parameters: Vmax and KM. These parameters are crucial in how the drug behaves inside the body after administration.
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
105
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance
105
Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
105
Drug Delivery: Parenteral Route
644
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
644


