白物质通道在第一发精神病中与听觉幻觉有差异相关:一种相关的通道图谱扩散光谱成像研究
Dean F Salisbury1, Dylan Seebold1, Julia M Longenecker2
1Clinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Schizophrenia research
|June 15, 2023
概括
第一次精神病发作的听觉幻觉与大脑电路中微妙的白质变化有关. 额頭--连接的这些变化会影响感官,语言和认知控制过程.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 听觉幻觉 (AH) 是精神病的一个重要症状,影响日常功能和认知.
- 目前的理论表明,AH源于大脑远程通信网络的中断,特别是在听觉,语言和认知控制系统中.
- 以前的研究表明,在特定区域的AH严重程度和白质完整性之间存在逆相关性,但需要进行更广泛的分析.
研究的目的:
- 用数据驱动方法调查听觉幻觉严重程度与全脑白质完整性之间的关联.
- 在患有第一发精神病 (FEP) 个体中,确定涉及AH表达的特定白质区域.
主要方法:
- 采用全脑,数据驱动的相关通道图分析,对175名FEP患者的扩散光谱成像 (DSI) 数据进行分析.
- 使用定量异位素 (QA) 量化白质完整性.
- 检查了各种白质道的质量保证与听觉幻觉的严重程度之间的关联.
主要成果:
- 在多个白质通道 (FDR < 0.001 和 FDR < 0.01) 中发现了定量异位性 (QA) 和AH严重程度之间的显著关联.
- 增加的AH严重程度与不同区域的增加和减少QA相关.
- 受影响的路径主要涉及前额--部连接,包括带膜束和前额外半球间路径.
结论:
- 在分布的神经回路,特别是连接额叶,额叶和叶的神经回路的微妙白质变化与FEP的听觉幻觉有关.
- 这些发现突出了感官感知,语言和认知控制网络功能障碍在AH中的作用.
- 了解这些复杂的神经回路可能为开发有针对性的干预措施铺平道路,例如非侵入性脑刺激.
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