心率的变化作为一种新的结倾向的标志物在帕金森病中
Benedetta Heimler1, Or Koren1, Rivka Inzelberg2
1Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Ramat Gan, Israel.
Parkinsonism & related disorders
|June 15, 2023
概括
患有帕金森病 (PD) 的个人经历了步态结 (FoG),在休息时显示心率变化 (HRV) 降低. 这种自主神经系统 (ANS) 失衡可能预测FOG倾向,提供新的诊断见解.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 自主神经科学 自主神经科学
背景情况:
- 步态结 (FoG) 是晚期帕金森病 (PD) 中的一个致残运动症状.
- 自主神经系统 (ANS) 在FOG情节周围显示生理变化.
- 休息时的ANS活动与FoG倾向之间的联系尚未得到充分理解.
研究的目的:
- 调查休息自主神经系统 (ANS) 活动是否可以预测帕金森病 (PD) 中即将发生的步态结 (FoG) 事件的倾向性.
主要方法:
- 心率变化 (HRV) 在患有PD和FoG (PD + FoG) 和老年人对照 (EC) 的个人中被记录在静止状态下.
- PD + FoG参与者接受了FOG触发事件的步态试验,分类为经历FOG (PD + FoG+) 或没有经历FOG (PD + FoG-).
- HRV分析的重点是心率间隔的波动,反映了大脑与心脏的相互作用.
主要成果:
- 与PD + FoG-和EC参与者相比,PD + FoG+患者的休息HRV显著降低,这表明自主失衡.
- 在PD+FOG和EC组中观察到更高的HRV,这表明自我调节能力得到保留.
- 当药物被启动时,群体之间没有发现HRV的显著差异,HRV与疾病持续时间或运动严重程度无关.
结论:
- 休息心率变化 (HRV) 与帕金森病 (PD) 中步态结 (FoG) 的存在或不存在显著相关.
- 这些发现突出了ANS功能障碍在FoG中的潜在作用,并建议HRV作为FoG倾向的生物标志物.
- 这项研究扩大了对ANS参与FoG病理生理学的理解.
相关概念视频
Parkinson's Disease: Overview
611
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
611
Factors Influencing Heart Rate
2.9K
The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
2.9K
Parkinson's Disease: Treatment
303
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
303
Dysrhythmias IV: Characteristics of Bradyarrhythmias
12
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
12
Regulation of Heart Rates
1.9K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
1.9K
Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K


