癌症与患高血压风险的关联
Hajime Nagasawa1,2, Hidehiro Kaneko1,3, Yuta Suzuki1,4
1The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
概括
患有癌症史的人面临患高血压的风险增加. 这种高风险适用于活跃的癌症患者和缓解期的癌症患者,突出了严重的公共卫生问题.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 高血压是癌症患者已知的并发症.
- 有限的数据存在于癌症幸存者的高血压风险.
研究的目的:
- 为了调查患有癌症史的人群发生高血压的风险.
- 为了比较癌症幸存者和普通人群之间的高血压发病率.
主要方法:
- 使用JMDC索赔数据库 (2005-2022) 进行的回顾性观察队列研究.
- 包括78,162名癌症患者和3,692,654名对照患者.
- 主要终点:使用多变量考克斯回归分析的高血压发生率.
主要成果:
- 与没有癌症的人 (247.2/10,000人年) 相比,有癌症史的人患高血压的发病率更高 (364.6/10,000人年).
- 癌症史与高血压风险增加有关 (危险比:1.17,95% CI:1.15-1.20).
- 在接受活性抗瘤疗法 (HR: 2.01) 和不需要它 (HR: 1.14) 的患者中观察到风险增加.
结论:
- 患有癌症史的个人表现出明显更高的患高血压的风险.
- 这种增加的风险存在,无论患者是否正在接受活跃的癌症治疗.
- 这些发现强调了对癌症幸存者进行警的心血管监测的必要性.
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