相关实验视频

Updated: Jul 26, 2025

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

LINC01116对患者生存的影响不同,并且在ER+和ER-乳腺癌样本中表达不一样

Mohammadjavad Karimi Taheri¹, Sogol Ghanbari¹, Akram Gholipour²

¹Molecular Genetics Department, Biological Sciences Faculty, Tarbiat Modares University, Tehran, Iran.

Cancer reports (Hoboken, N.J.)

|June 15, 2023

概括

长非编码RNA LINC01116 在乳腺癌中被上调,特别是在ER+组织中. 它的表达根据雌激素受体状态不同地影响患者的生存,这表明它是一种潜在的生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳腺癌是全球癌症死亡的主要原因之一.
长非编码RNAs (lncRNAs) 的异常表达与瘤的进展和发展有关.

研究的目的:

为了评估LINC01116在乳腺癌组织中的表达模式.
调查LINC01116对乳腺癌患者存活率的影响.
探索LINC01116在雌激素受体阳性 (ER+) 和雌激素受体阴性 (ER-) 乳腺癌中的作用.

主要方法:

对微阵列和qRT-PCR数据的分析.
使用KM-plotter数据库进行生存分析.
在乳腺癌细胞系中使用了体外功能增益测试.

主要成果:

与ER-组织相比,LINC01116在ER+瘤组织中显著上调.
与正常组织相比,LINC01116表达在ER+瘤组织中增加,在ER-瘤组织中减少.
在所有和ER+患者中,LINC01116与存活率呈正相关性,但在ER-患者中呈负相关性.
过度表达LINC01116诱导了ER细胞中的TGF-β信号传递,并且在接受17β- Estradiol治疗的MCF7细胞中被上调.

结论:

LINC01116作为一种潜在的生物标志物,用于区分ER+和ER-乳腺癌组织.
根据ER状态,LINC01116对患者的生存有不同的影响.
LINC01116通过调节TGF-β和雌激素受体信号通路来影响患者的结果.

关键词:

现在我们来看看LINC0111616的情况.在TGF-β的基础上.乳腺癌乳腺癌乳腺癌雌激素受体的受体是雌激素受体.在ncRNA中,我们可以看到

更多相关视频

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

相关概念视频

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...