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使用ACE2的与MERS相关的冠状病毒的广泛宿主热带以及限制病毒识别的决定因素

Chengbao Ma1, Chen Liu1, Qing Xiong1

  • 1State Key Laboratory of Virology, Institute for Vaccine Research and Modern Virology Research Center, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei, China.

Cell discovery
|June 15, 2023
PubMed
概括

两个中东呼吸综合征冠状病毒 (MERS-CoV) 相关的病毒,NeoCoV和PDF-2180,表现出广泛的哺乳动物ACE2受体识别,表明潜在的动物感染风险. 它们的宿主范围受到特定的ACE2相互作用的影响,特别是残留物305.

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