细菌通过表型塑性细胞集群的遗传同化而发展出宏观的多细胞性
Yashraj Chavhan1, Sutirth Dey2, Peter A Lind3,4
1Department of Molecular Biology, Umeå University, Umeå, Sweden. yashraj.chavhan@umu.se.
Nature communications
|June 15, 2023
概括
细菌可以通过环境诱导的细胞聚类来发展多细胞性. 由盐度变化驱动的表型可塑性,为细菌提供了基因同化多细胞性,甚至在大肠杆菌中也是如此.
科学领域:
- 进化生物学是进化的生物学.
- 微生物生态学 微生物生态学
- 遗传学 是一个遗传学.
背景情况:
- 从单细胞向多细胞的过渡是一个关键的进化事件.
- 关于多细胞性的实验进化研究主要使用了真核生物,并专注于突变驱动的特征.
- 细菌的多细胞性,特别是不分化的细胞群,是研究不足的领域.
研究的目的:
- 为了研究细菌中环境诱导的细胞聚类.
- 通过实验进化探索这种聚类表型的遗传同化.
- 了解细菌多细胞性的基因组基础和进化潜力.
主要方法:
- 在不同的度条件下,大肠杆菌的实验进化.
- 野生型和进化的细菌菌株的比较分析.
- 基因组测序以确定与同化多细胞性相关的突变.
主要成果:
- 格拉姆阴性和格拉姆阳性细菌都表现出环境诱导的细胞聚类,以应对高盐度.
- 实验进化导致大肠杆菌的基因同化多细胞性,形成了独立于环境线索的宏观集群.
- 细胞壁组装基因的突变被确定为进化多细胞性的基因组基础.
- 细胞形状和集群的表型可塑性是通过遗传同化进行调节的,有时是通过单一突变.
结论:
- 细菌细胞聚类中的表型可塑性可以作为多细胞性进化的前体.
- 环境诱导可以为复杂特征的遗传同化提供原始生物.
- 这项研究提供了细菌多细胞进化的早期阶段的见解.
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