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一个基于化学蛋白质基的目标识别电子亲和度标签平台

Yu Kawamata1, Keun Ah Ryu2, Gary N Hermann1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

Nature chemistry
|June 15, 2023
PubMed
概括

研究人员开发了一种新的电子亲和性标签平台,用于识别小分子药物标. 这种方法使用电化学氧化来激活化学探针,使活细胞中蛋白质的精确共价标记能够用于药物发现.

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Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...