小肠细菌过度生长的临床表现从气消化道细菌与结肠类型细菌相比:一项比较研究
Daanish A Siddique1, Claire L Jansson-Knodell2, Anita Gupta2
1Internal Medicine, Department of Medicine, Indiana University, Indianapolis, IN, USA.
Digestive diseases and sciences
|June 15, 2023
概括
这项研究发现,空气消化道 (ADT) SIBO与缺铁有关,而结肠类型的SIBO与结肠细菌的危险因素有关. 对于SIBO类型的独特临床特征需要进一步调查.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 内部医学 内部医学
背景情况:
- 小肠细菌过度生长 (SIBO) 是一种复杂的综合征,其特点是小肠中过多的细菌.
- 在SIBO中不同类型的细菌过度生长及其相应的临床表现之间的关系尚不清楚.
研究的目的:
- 研究空气消化道 (ADT) SIBO和结肠类型SIBO之间的症状,临床并发症,实验室发现和潜在风险因素的潜在差异.
- 为了比较被诊断患有ADT SIBO的患者的临床资料与结肠类型SIBO.
主要方法:
- 预期招募疑似SIBO患者,但不包括最近使用抗生素或益生菌的患者.
- 通过上肠镜检查,通过近接关吸收来诊断SIBO亚型:ADT SIBO (>10^5 CFU/mL口腔/呼吸道细菌) 和结肠类型SIBO (>10^4 CFU/mL远端小肠/结肠细菌).
- 收集临床特征,风险因素和实验室数据进行比较分析.
主要成果:
- 在144名受试者中,69名 (49%) 被诊断为SIBO.
- ADT SIBO显示,每天腹部膨胀的增加趋势 (65.2%与39.1%) 和铁缺乏症的显著增加 (33.3%与10.3%).
- 结肠型SIBO更频繁地与结肠细菌殖民的风险因素相关 (60.9%与17.4%相比),而ADT SIBO与胃酸减少的风险因素相关 (91.3%与67.4%相比).
结论:
- 在ADT和结肠类型SIBO之间观察到缺铁和潜在风险因素的差异.
- 这些SIBO亚型的独特临床症状概况尚未最终确定.
- 需要进一步的研究来开发有效的症状评估工具,并澄清SIBO的因果关系.
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