斯特雷普托米切斯多基提德 (Streptomyces polyketides) 在土壤环境中调解细菌-真菌相互作用
Mario K C Krespach1,2, Maria C Stroe1,3, Tina Netzker1,4
1Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI), Jena, Germany.
Nature microbiology
|June 15, 2023
概括
细菌和真菌之间的微生物相互作用是生态系统的关键. 来自Streptomyces物种的氨酸衍生型多基基化物 (arginoketides) 触发真菌天然产品合成,影响土壤微生物群落.
科学领域:
- 微生物学 微生物学
- 生态生态学 生态生态学
- 生物化学 生物化学
背景情况:
- 微生物相互作用对于生态系统的功能至关重要.
- 驱动微生物社区相互作用的过程尚未得到充分理解.
- prokaryotes 和 eukaryotes 之间的跨王国通信是必不可少的.
研究的目的:
- 研究细菌代谢物在微生物相互作用中介作用.
- 为了确定涉及跨王国通信的特定化合物.
- 了解这些相互作用如何影响天然产品生物合成.
主要方法:
- 从土壤样本中分离细菌和真菌.
- 细菌代谢物的化学分析,特别是氨酸衍生的多基化物 (arginoketides).
- 基因集群诱导试验和基因组分析.
主要成果:
- 斯特雷普托米切斯物种产生阿尔吉诺基提德,它们与真菌 (阿斯伯吉卢斯,尼西利姆) 进行介导相互作用.
- 阿扎洛米辛F是一种阿尔吉诺基化物,它诱导了阿斯伯吉卢斯尼杜兰斯菌中的奥塞林酸基因.
- 阿基诺基提德的生产者分布在全球的土壤环境中.
结论:
- 阿尔金诺基提德是跨王国微生物相互作用的关键调解者.
- 这些化合物触发了真菌中的二次代谢产物,影响了土壤生态系统.
- 阿基诺基提德有助于土壤微生物群落的结构和功能.
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