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NCI-MATCH试验:精密瘤学的经验教训

Peter J O'Dwyer¹, Robert J Gray², Keith T Flaherty³

¹University of Pennsylvania, Philadelphia, PA, USA. peter.odwyer@pennmedicine.upenn.edu.

Nature medicine

|June 15, 2023

概括

NCI-MATCH试验是一项针对耐火性癌症的大型精准医学研究,在25.9%的副研究中确定了向治疗方法. 这个平台试验为未来基因组驱动的癌症研究提供了宝贵的见解.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
临床试验临床试验

背景情况:

NCI-MATCH (治疗选择的分子分析) 试验是一项大型基因组驱动的精密医学平台试验,于2015年启动.
它专注于患有治疗不耐药的恶性固体瘤的患者,旨在将治疗方法与特定的基因组改变相匹配.

研究的目的:

评估针对性治疗在耐火固体瘤中具有特定基因组改变的患者的疗效.
评估信号寻找目标,即在广泛的患者群体中将疗法与分子标相匹配.

主要方法:

近6000名患者接受了查和分子测试.
1593名患者被分配到38个第二阶段副研究中,每个研究都测试了与基因组改变相匹配的疗法.
根据RECIST标准的客观瘤反应是每个子研究的主要终点.

主要成果:

NCI-MATCH试验实现了其信号搜索目标,27个初始替代试验中的7个 (25.9%) 显示了积极的结果.
这些发现表明,成功地确定了针对特定基因组变化的有效疗法.

结论:

NCI-MATCH试验证明了瘤不可知,精确瘤学方法的可行性和价值.
从其设计和操作行为中吸取的关键教训将为未来的精准医学研究提供信息.

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