周围化疗受体对增强的中央化疗反射驱动器在非缺血性心力衰竭中的作用
Katherin Pereyra1, Esteban Díaz-Jara1, Paulina Arias1
1Laboratory of Cardiorespiratory Control, Pontificia Universidad Católica de Chile, Santiago, Chile.
Advances in experimental medicine and biology
|June 15, 2023
概括
状体 (CB) 活动驱动心力衰竭 (HF) 中心化学反应增强. 破坏CB正常化呼吸和减少呼吸暂停,突出显示CB.
科学领域:
- 心血管生理学心血管生理学
- 呼吸系统控制 呼吸系统控制
- 神经科学是一个神经科学.
背景情况:
- 心力衰竭 (HF) 在老年人中很常见,并与呼吸障碍有关.
- 呼吸道化学反射强化,涉及状体 (CB) 和逆状核 (RTN),有助于HF的进展.
- 在HF中观察到增强的中央化学反射驱动和RTN活动,但潜在的机制尚不清楚.
研究的目的:
- 为了调查心脏机体 (CB) afferent 活动是否对于心脏衰竭 (HF) 中的逆转皮质核 (RTN) 化学敏感性增加是必要的.
- 确定CB afferent活动在中枢化学反射强化和呼吸障碍中的作用,在非胰岛症HF的老鼠模型中.
主要方法:
- 创建了一个非缺血性心力衰竭 (HF) 的老鼠模型.
- 在HF大鼠中进行CB化,以评估 afferent CB活动的影响.
- 在具有和没有功能性CBs的高频老鼠中测量了中央和外围化学反射驱动和呼吸模式 (包括呼吸暂停).
主要成果:
- 冠状动脉体 (CB) afferent活动对于心力衰竭 (HF) 中心化学反射驱动的强化至关重要.
- 在HF大鼠中,CB缩使中央化学反射驱动正常化.
- 在HF大鼠中,CB化显著降低了呼吸暂停的发病率,使其减少了两倍.
结论:
- 在心力衰竭 (HF) 中,CB afferent活动在增强中心化学反射方面发挥着关键作用.
- 准CB afferent通路可能为管理与高频率相关的呼吸障碍提供治疗策略.
- 这些发现阐明了HF病理生理学中外围和中央化学受体之间的相互作用.
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