在衰老中 Carotid 体介导的化学反射功能和受体相互作用蛋白激酶的作用
Esteban Díaz-Jara1, Karla G Schwarz1, Angelica Ríos-Gallardo1,2
1Laboratory of Cardiorespiratory Control, Pontificia Universidad Católica de Chile, Santiago, Chile.
Advances in experimental medicine and biology
|June 15, 2023
概括
衰老会损害心动脉体 (CB) 的功能,可能是通过RIPK3-介导的亡. 缺乏RIPK3的老年小鼠保持了正常的呼吸反应,这表明这种途径驱动了与年龄相关的呼吸系统衰退.
科学领域:
- 生理学 生理学 生理学
- 细胞生物学 细胞生物学
- 老年学是一门学科.
背景情况:
- 衰老与呼吸系统功能障碍有关,这与动体 (CB) 功能障碍和退化有关.
- 在衰老过程中驱动CB退化的精确机制,包括编程细胞死亡途径,仍然不清楚.
- 亡,一种编程细胞死亡的形式,与低级炎症有关,这是衰老的标志.
研究的目的:
- 为了研究受体相互作用蛋白激酶-3 (RIPK3) 依存性亡在与年龄相关的带体 (CB) 功能障碍中的作用.
- 为了确定抑制RIPK3-介导的亡是否可以预防呼吸系统衰退和衰老期间的呼吸障碍.
主要方法:
- 使用了成年和老年野生型 (WT) 和RIPK3淘汰赛 (RIPK3-/-) 鼠标.
- 评估缺氧呼吸反应 (HVR) 和高呼吸反应 (HCVR),以评估化学反射功能.
- 对老年小鼠呼吸障碍的流行情况进行监测.
主要成果:
- 在WT小鼠中,衰老显著降低了HVR和HCVR.
- 年龄较大的RIPK3-/-小鼠表现出保存的HVR和HCVR,与成年WT小鼠相似.
- 在老年WT小鼠中观察到的呼吸障碍的高患病率在老年RIPK3-/-小鼠中不存在.
结论:
- 在衰老过程中,RIPK3介导的亡在动脉器官 (CB) 功能障碍中起着重要作用.
- 向RIPK3依赖性亡可能提供一种治疗策略,以减轻与年龄相关的呼吸系统衰退和呼吸障碍.
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