测试异型并不能帮助区分类风湿性关节炎和其他类风湿因子阳性疾病
Maria Infantino1, Boaz Palterer2, Maurizio Benucci3
1Laboratorio di Immunologia e Allergologia, Ospedale S. Giovanni di Dio, Via Torregalli, 3, 50143, Firenze, Italy. maria2.infantino@uslcentro.toscana.it.
Immunologic research
|June 15, 2023
概括
通过脑膜测量检测到的类风湿性因素 (RF) 对类风湿性关节炎 (RA) 诊断有用. 然而,对IgA,IgG和IgM射频的同型特异性测试并没有显著改善RA和其他射频阳性疾病之间的差异化.
科学领域:
- 免疫学 免疫学 免疫学
- 临床化学 临床化学
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性因素 (RFs) 是关键的生物标志物,用于类风湿性关节炎 (RA) 的诊断和分类.
- 目前常规的诊断方法,如鼻膜测量检测到总RF,但缺乏同型特异性 (IgA,IgG,IgM).
- 异型特异性免疫试验的进步为完善射频诊断提供了机会.
研究的目的:
- 评估同型特异射频测试作为传统鼻膜测量后的第二阶段诊断方法的实用性.
- 确定IgA,IgG和IgM射频检测是否可以区分类风湿性关节炎 (RA) 和其他射频阳性疾病.
主要方法:
- 通过脑膜测量分析了最初为RF阳性的血清样本 (n=117).
- 以同型为特征的RF (IgA,IgG,IgM) 用免疫酶分析 (FEIA) 来量化.
- 在RA患者 (n=55) 和非RA患者 (n=62) 之间比较了结果.
主要成果:
- 18个样本 (15.4%) 仅通过脑膜测量结果呈阳性;两个仅对IgA RF呈阳性.
- 97个样本对IgM RF呈阳性,有或没有IgA和IgG RF.
- 在射频同型和RA诊断之间没有发现显著的相关性;与总射频的相关性是中度到弱的.
结论:
- 同型特异性射频测试没有有效地区分RA与其他射频阳性条件,当使用作为第二级测试后nephelometry.
- 尽管有局限性,通过鼻膜测量进行全射频测量仍然是一个有价值的诊断方法.
- 作为RA的二次诊断标记物,IgA,IgG和IgM射频同型的临床实用性目前存在争议.
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