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一个具有双功能单体的分子印记电化学传感器,用于选择性地确定gatifloxacin

Yan Huang¹, Xuyuan Sun¹, Jing Yang¹

¹Department of Chemistry, College of Sciences, Shanghai University, Shanghai, 200444, People's Republic of China.

Mikrochimica acta

|June 15, 2023

概括

开发了一种使用双功能单体的新型电化学传感器,用于敏感的gatifloxacin (GTX) 检测. 该传感器在水样中的抗生素污染物分析中表现出高特异性和低检测极限.

科学领域:

电化学电化学电化学
材料科学材料科学材料科学
环境科学环境科学

背景情况:

抗生素耐药性需要准确检测制药污染物.
开发选择性和敏感的电化学传感器对于环境监测至关重要.
加蒂夫洛克萨 (GTX) 是一种广泛使用的抗生素,其环境存在需要监测.

研究的目的:

设计和制造一个分子印制的电化学传感器,用于选择性地测定gatifloxacin (GTX).
研究双重功能单体和纳米材料的协同效应,以提高传感器性能.
为了评估传感器在真实水样中的适用性,用于抗生素污染物的分析.

主要方法:

在玻璃碳电极上制造分子印记聚合物 (MIP) 薄膜,使用双功能单体 (p-氨基酸和尼古丁胺) 和GTX作为模板.
集成的多壁碳纳米管 (MWCNT) 和二氧化石的imidazolate框架8 (ZIF8) 增强传感器的性能.
使用循环电压测量和电化学阻抗光谱学进行电化学表征,使用[Fe(CN) ₆^3-/4-作为氧化还原探针.
验证传感器性能,包括线性范围,检测极限,特异性和真实水样中的回收.

主要成果:

开发的MIP双重传感器与单个单体的传感器相比,对GTX具有显著增强的特异性.
传感器展示了一个广泛的线性范围从1.00 × 10-14到1.00 × 10-7 M.
实现了2.61×10−15M的显著低的检测极限.
在真实水样中获得了令人满意的回收率 (96.5105%) 和较低的相对标准偏差 (2.43.7%).

结论:

基于双功能单体和纳米材料的分子印记电化学传感器为GTX确定提供了一个高度选择性和敏感的平台.
协同集成MWCNT和ZIF8显著提高了传感器的性能.
该传感器在环境水样中的抗生素污染物监测中具有很大的实际应用潜力.

关键词:

微分脉冲电压测量微分脉冲电压测量双重功能单体是双重功能单体.电化学传感器是一种电化学传感器.盖蒂夫洛克萨辛是一种有分子印记的聚合物.

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