用永久填充的Ge-phantom测量PET图像质量和量化的变化:一个多中心研究
O Sipilä1, J Liukkonen2, H-L Halme3
1HUS Diagnostic Center, Clinical Physiology and Nuclear Medicine, Helsinki University Hospital and University of Helsinki, P. O. Box 442, 00029, Helsinki, Finland. outi.sipila@hus.fi.
EJNMMI physics
|June 15, 2023
概括
这项研究评估了使用幻影的芬兰PET/CT扫描仪的变异性. 结果显示,定量准确度的变化很大,但大多数扫描仪通过优化满足认证标准.
科学领域:
- 核医学就是核医学.
- 医学成像物理 医学成像物理
背景情况:
- 芬兰临床PET [18F]FDG全身方案的定量准确性和图像质量 (IQ) 的评估变异性.
- 使用一个充满68Ge的NEMA/IEC智商幻影进行快照评估.
研究的目的:
- 评估临床上使用的PET [18F]FDG全身协议的量化和图像质量的变异性.
- 为了将恢复系数 (RCs) 与 EARL 18F 标准 2 认证 (EARL2) 限制进行比较.
- 为了研究图像噪声对定量参数的影响.
主要方法:
- 在两个供应商的14台PET-CT扫描仪上成像了一个NEMA/IEC智商幻影.
- 测量RCs (RCmax,RCmean,RCpeak) 的变化率,百分比背景变化率 (PBV),背景变化系数 (COV_BG) 和校正精度 (AOC).
- 使用临床和标准化协议进行了20次重复测量,并分析了平均图像 (AVI) 来研究图像噪声的影响.
主要成果:
- 常规方案显示RCmax的变化率高达68%,在排除的情况下降至36%. 扫描器内部的变化率为10%.
- 大多数RC都符合EARL2范围,但确切的极限在变化方面得到了满足. RCpeak 的性能比 RCmax 和 RCmean 的性能更强大.
- PBV,COV_BG和AOC各有所不同 (分别为2.3-11.8%,9.6-17.8%,4.8-32.0%). 平均图像降低了RC范围,PBV和COV_BG. 没有点传播函数 (PSF) 校正的协议显示AOC.较高.
结论:
- [18F]FDG协议的RC值的最大变化大约为60%.
- 适当的交叉校准的扫描仪与PSF校正通常满足EARL2 RC范围,但需要进一步优化精确的限制.
- RCpeak显示出对图像噪声的最强健性;与COV_BG不同的是,RC和PBV对噪声敏感.
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