相关实验视频
Updated: Jul 26, 2025
04:23
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
402
骨髓缩症的患病率和危险因素:一个系统性审查和元分析
Tianjin Huang1,2, Chen Li1,2, Faxiu Chen3
1Medical College of Nanchang University, Nanchang, China.
BMC geriatrics
|June 15, 2023
概括
骨质疏松症是一种结合了骨质疏松症和骨质疏松症/骨质疏松症的疾病,影响了21%的老年人. 女性性别,年龄较大和先前的骨折是关键的危险因素,需要综合管理策略.
科学领域:
- 老年学是一门学科.
- 骨和肌肉健康 骨和肌肉健康
- 代谢疾病 代谢疾病
背景情况:
- 骨质疏松症,其特点是同时出现骨质疏松症和骨质疏松症/骨质疏松症,显著增加了虚弱,跌倒,骨折,住院和死亡的风险.
- 这种情况给老年人和全球医疗保健系统带来了巨大的负担.
- 了解骨质疏松症的患病率和风险因素对于有效的临床管理至关重要.
研究的目的:
- 系统地审查骨质疏松症的流行情况.
- 为了识别与骨质疏松症相关的关键风险因素.
- 为临床实践和公共卫生战略提供必要的参考资料.
主要方法:
- 通过31项研究的数据进行了全面的元分析.
- 在主要数据库 (PubMed,Embase,Web of Science等) 进行了搜索. 在2022年4月之前.
- 患病率和风险因素数据使用随机或固定效应模型进行了聚合,并进行了严格的偏差和灵敏度分析.
主要成果:
- 发现骨质疏松症的总体患病率为21% (95% CI:0.16-0.26),单个研究的患病率从1.5%到65.7%不等.
- 确定的重大风险因素包括女性性别 (OR 5.10),年龄较大 (OR 1.12) 和骨折史 (OR 2.92).
- 统计分析证实了这些与高置信区间相关的关联.
结论:
- 骨髓缩症的患病率很高,这强调了它作为老年综合征的重要性.
- 女性的性别,晚年和骨折史独立地与骨髓缩症有关.
- 综合,多学科的管理方法对于解决这种复杂的情况至关重要.
相关概念视频
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
01:40Bone Remodeling
38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
01:09Changes in the Appendicular Skeleton with Age
2.1K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.1K
01:02What is the Skeletal System?
53.0K
Overview
53.0K
01:25Role of Vitamins in Maintaining Bone Health
3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K