世界卫生组织基于实验室与非实验室的风险方程,用于评估心血管疾病风险
Azizallah Dehghan1, Ali Rayatinejad2, Rozhan Khezri3
1Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
BMC medical research methodology
|June 15, 2023
概括
世卫组织基于非实验室的心血管风险模型与其基于实验室的对应模型有很大的一致性. 这使得它成为在资源有限的环境中进行风险评估的可行工具.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 世界卫生组织 (WHO) 提供心血管疾病风险预测模型.
- 这些模型存在于实验室和非实验室形式.
- 实验室设施的可访问性可能是某些医疗保健机构的障碍.
研究的目的:
- 评估基于实验室和非实验室的世卫组织心血管风险方程之间的一致性.
- 评估非实验室模型对心血管风险预测的有用性.
主要方法:
- 一项采用Fasa队列6796名个体的基线数据的横截面研究.
- 风险因素的比较:实验室模型 (年龄,性别,SBP,糖尿病,吸烟,总胆固醇) 与非实验室模型 (年龄,性别,SBP,吸烟,BMI).
- 统计分析包括分组风险协议的卡帕系数和得分协议的布兰德-阿尔特曼图.
主要成果:
- 在一般人群中,两种模型之间发现了实质性的一致性 (kappa=0.68).
- 同意度因年龄和性别而异,总体上有实质性的同意,尽管在老年人群中适度.
- 非实验室模型显示了可接受的灵敏度 (例如,在10%风险值的几个子组中100%),用于识别高风险个体.
结论:
- 世卫组织基于非实验室的心血管风险模型与基于实验室的版本有很好的一致性.
- 非实验室模型在资源有限的环境中为实际风险评估提供了可接受的灵敏度.
- 这种模型适合在实验室访问受到限制的查计划.
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