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在IgA脏病中,氧化和全身性皮质类固醇之间的比较:为期两年的随访研究
Feng-Lei Si1,2,3, Chen Tang1,2,3, Ji-Cheng Lv1,2,3
1Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China.
BMC nephrology
|June 15, 2023
概括
氧化 (HCQ) 在24个月内有效控制IgA脏病 (IgAN) 中的蛋白尿症,与皮质类固醇 (CSs) 相比. HCQ提供了一种安全的替代方案,具有较少的不良事件,保持稳定的功能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 为了减少蛋白尿症,IgA脏病 (IgAN) 通常用氧化 (HCQ) 治疗.
- 在Igan中,HCQ与全身皮质类固醇 (CS) 的长期疗效和安全性尚未得到充分证实.
研究的目的:
- 为了比较HCQ与CS治疗对Igan患者蛋白尿和功能的长期影响.
- 评估HCQ与Igan管理中的CS相比的安全概况.
主要方法:
- 北京大学第一医院的回顾性病例对照研究.
- 接受HCQ≥24个月 (没有其他免疫抑制剂) 的39名Igan患者与接受CS治疗的39名Igan患者进行了匹配.
- 临床数据,包括蛋白尿和估计的淋巴细胞过率 (eGFR),在24个月内进行了比较.
主要成果:
- 24个月后,HCQ和CS两组都显示出显著的蛋白尿减少 (HCQ:-50.5%;CS:-63.7%),两组之间没有显著差异 (P=0.707).
- 在HCQ和CS组之间观察到eGFR的可比下降率 (-7.9%对 -6.6%,P=0.758).
- 与HCQ组相比,CS组发生的不良事件更多.
结论:
- 长期用氧化 (HCQ) 治疗IgA脏病 (IgAN) 维持稳定的功能,副作用最小.
- HCQ为Igan患者提供了安全有效的支持性治疗选择,特别是那些对皮质类固醇不耐受的人.
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