儿童和新生儿血栓形成的流行病学和危险因素:系统评估和元分析
Shuang Song1, Zhuowei Li2, Guozhen Zhao3
1Integrative Medicine Institute, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
BMC pediatrics
|June 15, 2023
概括
这次元分析确定了儿科和新生儿重症监护病房中血栓形成的关键风险因素. 中枢静脉导管,感染/败血症,机械通风和手术显著增加了重症儿童的血栓形成风险.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 新生儿重症监护室新生儿重症监护室
- 血管医学是一种血管医学.
- 流行病学 流行病学
背景情况:
- 血栓形成对儿童和新生儿构成重大健康风险.
- 儿科和新生儿血栓形成的确定的风险因素仍然不完全理解.
- 准确识别血栓形成风险因素对于有效的临床管理至关重要.
研究的目的:
- 系统地识别和量化儿科和新生儿重症监护室 (ICU) 患者血栓形成的风险因素.
- 为临床实践提供信息,并指导针对儿科和新生儿血栓瘤的有针对性的预防策略的制定.
主要方法:
- 进行了全面的元分析,系统地搜索多个电子数据库,直到2022年5月.
- 包括的研究被分析为出版年,设计,起源,患者数量,种族和血栓类型.
- 使用固定或随机效应模型计算聚合概率比率 (ORs) 和95%置信区间 (CI),并评估出版偏差和异质性.
主要成果:
- 分析包括18项研究,显示儿童年血栓发生率为2%.
- 确定的重大危险因素包括中央静脉导管 (OR=3.66),手术 (OR=2.25),机械呼吸 (OR=2.1),感染/败血症 (OR=1.95).
- 妊娠年龄 (OR=1.5) 和呼吸困难 (OR=1.39) 也与血栓形成风险增加有关,而种族显示出非显著的趋势 (OR=0.88).
结论:
- 中枢静脉导管,手术,机械通风,感染/败血症,妊娠年龄和呼吸困扰是儿童和新生儿ICU患者血栓形成的重要危险因素.
- 这些已识别的风险因素可以帮助临床医生识别高风险个体.
- 这些发现支持制定和实施量身定制的预防措施,以减轻重症儿童和新生儿的血栓形成.
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