在严重的COVID-19肺炎后持续存在的临床显著的扩散性帕伦基马肺异常的危险因素
Sahajal Dhooria1, Siddhant Arora2, Shivani Chaudhary1
1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
The Indian journal of medical research
|June 16, 2023
概括
较长的住院时间与严重的COVID-19后持续的肺部异常有关. 转化生长因子-β (TGF-β) 可能成为这些扩散性帕伦基马肺异常 (CS-DPLA) 的未来生物标志物.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 临床上显著的扩散性膜肺异常 (CS-DPLA) 可以在严重的COVID-19肺炎后持续存在,但风险因素仍然不清楚.
- 了解这些风险因素对于管理COVID-19后的长期呼吸道并发症至关重要.
研究的目的:
- 评估COVID-19严重程度参数与CS-DPLA的发展之间的关联.
- 确定严重COVID-19后持续性CS-DPLA的独立预测因素.
主要方法:
- 一项队列研究,包括患有和没有CS-DPLA的患者在严重COVID-19后的2个月和6个月.
- 后勤回归分析被用来识别预测因子,中性粒细胞-淋巴细胞比率 (NLR) 作为主要暴露.
- 血清中表面活性蛋白D,癌症抗原15-3和转化生长因子β (TGF-β) 的水平进行了比较.
主要成果:
- 超过56%的参与者在2个月后患有CS-DPLA,在6个月后降至29%.
- 虽然NLR,峰值LDH,ARS和LOS显示了单变联,但仅住院时间长度 (LOS) 独立预测了CS-DPLA在两个时间点.
- 与健康志愿者相比,6个月后CS-DPLA患者的血清TGF-β水平较高.
结论:
- 长时间住院是严重COVID-19后六个月持续性CS-DPLA的唯一独立预测因素.
- 血清TGF-β值得进一步研究,因为它是预测或监测CS-DPLA的潜在生物标志物.
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