大脑形态测量表明,在童年2年的时间里,精神病,抑郁症和焦虑脆弱性的新兴模式出现了
Teresa G Vargas1, Vijay A Mittal1
1Northwestern University, Swift Hall 102, 2029 Sheridan Road, Evanston, IL 60201, USA.
Psychological medicine
|June 16, 2023
概括
童年后期的大脑结构差异可能预测未来的心理健康状况. 这些发现提供了对早期易受抑郁症,焦虑症和精神病类似经历等疾病的洞察.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 灰质形态测量研究对于理解精神疾病病因至关重要.
- 以前的研究主要集中在成年人群和单一疾病上.
- 在童年后期检查大脑特征,为新兴的精神病理学提供了独特的视角.
研究的目的:
- 为了研究童年后期的大脑形态测量.
- 为了识别心理病理学大脑脆弱性的常见和独特的模式.
- 预测精神病类经历,抑郁和焦虑症状的开始和进展.
主要方法:
- 在青少年大脑和认知发展研究中利用了8645名年轻人的数据.
- 收集了磁共振成像扫描和评估症状超过两年.
- 分析皮层厚度,表面积和皮层下体积,以预测症状.
主要成果:
- 确定了共同的脆弱性标志物 (例如,上额,中部区域),预测了精神病理的进展.
- 发现了类似精神病体验的独特预测模式 (侧头,前中心厚度).
- 观察到焦虑的特定预测因子 (体厚度/面积,环膜) 和抑郁 (近海马,下).
结论:
- 心理病理学的常见和明显的脆弱性模式存在于童年后期.
- 这些模式在青少年大脑重组之前就出现了.
- 这些发现与制定早期预防和干预策略有关.
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