色素受体2A和色素受体1A基因中的单核酸多态体之间的关联以及根运河治疗后的疼痛
Sandra Regina Santos Meyfarth1, Jhenyfer da Silva Tavares2, Ludmila da Silva Guimarães1
1Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Brazil.
International endodontic journal
|June 16, 2023
概括
血清素和黑色素受体的遗传变异会影响根管治疗后的术后疼痛. 在HTR2A和MTNR1A基因中的特定单核酸多态 (SNPs) 与增加疼痛感知有关,为疼痛管理提供了洞察力.
科学领域:
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
- 牙周内科医院 牙周内科医院 牙周内科医院
背景情况:
- 根管治疗后的术后疼痛可以显著影响患者的康复和生活质量.
- 了解影响疼痛感知的遗传因素对于个性化疼痛管理策略至关重要.
研究的目的:
- 调查5 - 三胺 (血清素) 受体2A (HTR2A) 和黑素受体1A (MTNR1A) 基因中的单核酸多态 (SNPs) 与根运河治疗后的术后疼痛之间的关联.
- 确定HTR2A和MTNR1A基因中的特定SNP是否有助于在接受内牙治疗的患者疼痛感知的变化.
主要方法:
- 一项基因队列研究,涉及108名患者,他们接受了单次根管治疗,以治疗肉死和无症状的牙牙周炎.
- 经手术后的疼痛和疼痛感受到的疼痛和疼痛感受到的疼痛和疼痛感受到的疼痛和疼痛感受到的疼痛和疼痛感受到的疼痛和疼痛感受到的疼痛和疼痛.
- 在HTR2A (rs4941573,rs6313) 和MTNR1A (rs6553010,rs6847693,rs13140012) 中的特定SNP的基因定型使用实时聚合酶链反应对从唾液中提取的DNA进行.
主要成果:
- 发现三个特定的SNP与患上术后疼痛的风险增加有显著的关联.
- 这些重要的SNP包括MTNR1A基因中的rs6553010和HTR2A基因中的rs4941573和rs6313 (p < .05).
结论:
- 在HTR2A和MTNR1A基因中的单核酸多态性在根管治疗后调节疼痛反应中起作用.
- 这些遗传发现表明,潜在的生物标志物可以预测和管理内牙患者的术后疼痛.
相关概念视频
Analgesia and Pain Management
668
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
668
Pain
518
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
518
Local Anesthetics: Differential Sensitivity of Nerve Fibers
879
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
879


