在孕期暴露于普拉佐辛后,对怀孕结果的前性评估
Natalie Zitoun1, M Karen Campbell1,2,3,4,5, Doreen Matsui2
1Department of Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada.
British journal of clinical pharmacology
|June 16, 2023
概括
在怀孕期间使用普拉佐辛的结果与一般人群的结果相似. 虽然需要更多的研究,但这项研究为意外接触到普拉佐辛的孕妇提供了保证.
科学领域:
- 药理学 药理学是指药理学的学科.
- 产科 产科 产科 产科 产科
- 周围生理学 周围生理学
背景情况:
- 普拉佐辛是一种抗高血压药物,也用于创伤后应激障碍 (PTSD).
- 关于孕期普拉佐辛的安全性存在有限的数据.
- 评估早期怀孕中普拉佐辛暴露的胎儿和怀孕安全性至关重要.
研究的目的:
- 评估在怀孕早期暴露于普拉佐辛的安全性.
- 为了将暴露于普拉佐辛的患者的怀孕结果与一般人口数据进行比较.
主要方法:
- 在怀孕早期接受普拉佐辛的11名患者的回顾性病例系列.
- 通过医疗记录和电话问卷收集的数据.
- 分析的结果包括流产,出生体重和母亲/新生儿不良事件.
主要成果:
- 54.5%的受试者报告没有任何不良结果.
- 发生了两次流产;剩下的9次怀孕的出生体重正常.
- 报告的不良事件 (孕,早产,新生儿重症监护室住院) 在预期的人口率内.
结论:
- 这个队列中的怀孕结果与未暴露的怀孕结果相似.
- 虽然没有确定性,但研究结果对意外的早期怀孕暴露令人放心.
- 需要进行进一步的研究,以确定普拉佐辛在怀孕期间的安全性.
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