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碳酸纳米颗粒介导的线粒体功能障碍,用于增强的声动疗法

Haoyuan Zhang¹, Xueting Pan¹, Qingyuan Wu¹

¹Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing P. R. China.

Exploration (Beijing, China)

|June 16, 2023

概括

碳酸纳米颗粒 (MnCO3 NPs) 通过产生反应性氧物种和激活亡,提供增强的声动疗法 (SDT). 这种新型的声敏化剂在体内有效抑制瘤生长.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

声动疗法 (SDT) 是一个有前途的非侵入性癌症治疗方法,利用超声波. 开发高效的声敏剂仍然是改善治疗结果的关键挑战.
目前的研究重点是用于增强反应性氧物种 (ROS) 生产和在SDT中向药物输送的新型纳米材料.

研究的目的:

开发和评估碳酸纳米颗粒 (MnCO3 NPs) 作为一种新的,高效的声敏化剂,用于增强声动力学瘤治疗.
研究MnCO3NP在产生ROS,诱导细胞死亡方面的机制,以及它们对超声波成像的潜力.

主要方法:

通过一种简单的方法合成碳酸纳米颗粒 (MnCO3 NPs).
评估MnCO3NP的声动力学特性,包括在超声波照射下产生1O2和OH.
评估MnCO3NP在酸性环境中的可降解性以及CO2和Mn离子的释放.
在体外研究细胞死亡和亡诱导.
在体内实验以评估瘤抑制率和治疗疗效.

主要成果:

在超声波下,MnCO3NP有效地产生大量的1O2和OH,增强声动力学效应.
在弱酸性环境中MnCO3NP的降解会释放二氧化碳泡,导致超声波化诱导的细胞亡,并使超声波成像成为可能.
释放的Mn离子激活了线粒体亡途径,导致瘤细胞死亡.
在体内研究显示出显著的瘤抑制率,证实了MnCO3NP在增强声动力瘤治疗中的有效性.

结论:

碳酸纳米颗粒 (MnCO3 NPs) 是一种新且有效的声敏化剂,用于增强声动力学瘤治疗.
涉及ROS生成,超声波化和线粒体亡激活的双作用机制有助于高治疗效率.
CO3NP显示出非侵入性癌症治疗的巨大潜力,将治疗效果与诊断能力相结合.

关键词:

碳酸是一种碳酸.进行线粒体调节.声动力学疗法是一种声动力学疗法.这是一个sonosensitizer.超声波化超声波化

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