在2型糖尿病患者中,糖尿病视网膜病变的严重程度与心脏功能之间的关联
YanYan Chen1, MengYing Li1, Yi Wang1
1Department of Endocrinology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, China.
Journal of diabetes research
|June 16, 2023
概括
糖尿病视网膜病变 (DR) 的严重程度与2型糖尿病 (T2DM) 中左心室结构和功能的恶化相关. 扩散性DR与较差的心脏结果和心电图异常有关.
科学领域:
- 心脏病学 心脏病学
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病视网膜病变 (DR) 是2型糖尿病 (T2DM) 的常见并发症.
- 在T2DM患者中,DR严重程度和心脏结构/功能之间的关系与保存的喷射分数尚未完全理解.
- 评估DR的心脏影响对于全面的糖尿病管理至关重要.
研究的目的:
- 研究糖尿病视网膜病变 (DR) 严重程度与左心室 (LV) 结构和功能之间的关联.
- 为了确定DR进展是否会影响2型糖尿病患者的心脏参数.
主要方法:
- 对790名T2DM患者的回顾性分析,这些患者的LV喷射分数保存.
- DR严重程度的分类:没有DR,早期非扩散性DR,中度至严重的非扩散性DR,以及扩散性DR.
- 用心电图 (ECG) 评估 LV 结构和功能,使用心声回声和心肌导电.
主要成果:
- 左心室室间隔膜厚度 (IVST) 随着DR严重程度显著增加 (P < 0.001).
- 扩散性DR独立地与较差的LV结构相关 (OR = 1.35,P = 0.026).
- 增加DR严重程度与心电图异常相关,包括心率,PR间隔和QTc间隔 (所有P<0.005).
结论:
- 扩散性糖尿病视网膜病变独立地与心脏结构和功能受损有关.
- 糖尿病视网膜病变的严重程度与T2DM患者心电图异常有显著的相关性.
- 这些发现凸显了DR对T2DM心血管健康的系统影响.
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