在非霍奇金淋巴瘤中对血管原生标记物的组织病理学评估
Priyanka Singh1, Anita Tahlan2,3, Harsh Mohan2
1Department of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
Journal of laboratory physicians
|June 16, 2023
概括
微血管密度 (MVD) 和血管内皮生长因子 (VEGF) 增加与非霍奇金病.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 血管新生研究研究
背景情况:
- 血管新生对于瘤的发展和进展至关重要.
- 在全球范围内,非霍奇金淋巴瘤 (NHL) 发病率正在上升.
- 了解瘤血管生成对于淋巴瘤治疗策略至关重要.
研究的目的:
- 在NHL中使用CD34.4评估微血管密度 (MVD).
- 评估NHL中的血管内皮生长因子 (VEGF) 表达.
- 为了将MVD和VEGF与NHL组织学等级相关联.
主要方法:
- 对60个预处理NHL胺嵌入组织样本的分析.
- 针对CD34进行免疫组织化学染色,以量化MVD.
- 对VEGF进行免疫组织化学染色,以评估表达水平.
主要成果:
- 随着较高的NHL组织学等级,MVD显著增加.
- 在T-NHL中,MVD的平均值 (183/mm2) 比B-NHL (79.5/mm2) 高.
- VEGF表达与MVD和NHL等级有很强的相关性;70%的病例显示VEGF表达,T-NHL病例显示100%的强表达.
结论:
- 由VEGF驱动的瘤血管生成潜力与NHL等级的进展.
- 高度淋巴瘤中MVD升高表明抗血管生成疗法的潜力.
- 在NHL中,VEGF和MVD是重要的预后标志物.
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