先进的策略,以逃避单核细胞系统清除纳米材料的先进策略
Junjie Lu1, Xiao Gao2, Siyao Wang2
1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials Science Northwest University Xi'an China.
Exploration (Beijing, China)
|June 16, 2023
概括
规避单核细胞系统 (MPS) 的策略对于纳米材料药物输送至关重要. 本综述探讨工程纳米材料和禁用MPS以提高治疗疗效.
科学领域:
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 纳米材料为改善药物的生物可用性和有针对性的输送提供了潜力.
- 单核细胞系统 (MPS) 构成了系统性纳米材料管理的重大障碍.
- 克服MPS清除对于有效的基于纳米材料的疗法至关重要.
研究的目的:
- 总结目前逃避单核细胞系统 (MPS) 清除纳米材料的策略.
- 探索工程纳米材料的方法,以减少MPS吸收.
- 检查禁用MPS以提高药物输送的方法.
主要方法:
- 对纳米材料的表面修饰技术的审查.
- 对纳米材料输送的细胞车策略的分析.
- 探索生理环境调制以减少MPS清除.
- 检查MPS阻塞和巨细胞抑制/消耗方法.
主要成果:
- 表面工程和细胞上车可以减少MPS的纳米材料清除.
- 调节生理环境也可以减少MPS吸收.
- 包括封锁和巨细胞操纵在内的MPS禁用方法提供了替代策略.
- 在优化这些逃避技术方面存在挑战和机遇.
结论:
- 有效地逃避MPS对于成功的纳米材料药物输送至关重要.
- 纳米材料工程和MPS调制策略的结合具有前景.
- 需要进一步的研究来应对挑战,并释放纳米材料疗法的全部潜力.
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