过度饮酒与较高的皮质醇和较低的海马和前额前部灰质体积有关:与未来的酒精摄入量有潜在的关联
Siyan Fan1, Elizabeth V Goldfarb1, Cheryl Lacadie2
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Neurobiology of stress
|June 16, 2023
概括
过度饮酒与更高的皮质醇和减少大脑灰质量在压力和记忆的区域. 这种结构性变化预测暴饮暴饮者未来的酒精消费量增加.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 成研究 研究成研究
背景情况:
- 皮质醇驱动压力反应,由酒精提高,特别是暴饮暴行 (BD).
- 过度饮酒 (BD) 与负面的健康结果,酒精使用障碍 (AUD) 和像海马体和前额皮层这样的大脑区域的变化有关.
- 之前的研究还没有同时检查灰质体积 (GMV) 和皮质醇与BD和未来酒精摄入量相关的情况.
研究的目的:
- 调查暴饮暴饮 (BD) 对结构性灰质量 (GMV) 和皮质醇水平的同时影响.
- 为了检查海马和前额前部GMV,皮质醇和未来酒精摄入量之间的潜在关系.
主要方法:
- 结构性MRI扫描用于量化报告过度饮酒 (BD,N=55) 和中度饮酒 (MD,N=58) 个体的区域GMV.
- 基于全脑素的形态测量被用于GMV量化.
- 一部分参与者接受了30天的前性每日酒精摄入量评估后扫描.
主要成果:
- 与中度饮酒者 (MD) 相比,狂饮者 (BD) 在海马体,背侧前额叶皮质 (dlPFC),运动,感觉和表皮质中表现出较高的皮质醇水平和显著较小的GMV.
- 在dlPFC和运动皮层中较小的GMV与皮质醇水平负相关.
- 在前额区域减少的GMV预测了BD个体中随后饮酒日数的增加.
结论:
- 过度饮酒 (BD) 与神经内分泌和结构性大脑变化有关,包括在关键大脑区域增加皮质醇和降低GMV.
- 在对压力,记忆和认知控制至关重要的区域观察到较低的GMV在BD个体中.
- 降低认知控制和运动区域的GMV预测过度饮酒者未来的酒精消费量更大,突出了AUD风险的潜在生物标志物.
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