在移植后患者糖尿病管理中使用-葡萄糖共运输体-2 抑制剂
Erica F Crannage1, Katherine L Nguyen1, Morgan D Ellebrecht1
1St. Louis College of Pharmacy, University of Health Sciences & Pharmacy in St. Louis, St. Louis, MO, USA.
概括
-葡萄糖共传输体-2 (SGLT2) 抑制剂可能对接受移植的人的糖尿病管理有好处. 然而,需要更多的研究来确认它们在这个人群中的长期安全性和有效性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病是移植接受者 (KTR) 常见的并发症.
- 在移植后,优化血糖控制,同时确保移植和患者安全至关重要.
- -葡萄糖共运输体-2 (SGLT2) 抑制剂是抗糖尿病药物的一类,在一般糖尿病人群中具有既定的益处.
研究的目的:
- 审查和综合有关SGLT2抑制剂在KTR中的安全性和有效性的现有数据.
- 评估SGLT2抑制剂对血糖控制,体重和其他KTR相关参数的影响.
- 在移植后的环境中确定与SGLT2抑制剂使用相关的潜在风险和益处.
主要方法:
- 在PubMed,EMBASE和clinicaltrials.gov数据库中进行全面的文献搜索.
- 包括英语出版的研究,重点是用SGLT2抑制剂治疗的KTR.
- 从案例系列,回顾性分析,前性观察性研究和随机对照试验中分析数据.
主要成果:
- 在选择的KTR中,SGLT2抑制剂可能会对血糖控制,体重和血清尿酸水平提供适度的改善.
- 报告有尿路感染,但通常发生在较低的发病率.
- 关于长期死亡率和移植存活率的数据有限,尽管一些研究表明潜在的益处.
结论:
- 在特定的KTR中,SGLT2抑制剂显示出作为糖尿病管理的辅助疗法的潜力.
- 目前的证据受到小样本大小,多样化的种群和短期随访持续时间的限制.
- 需要进行进一步的强有力的研究,以确定KTR中SGLT2抑制剂的最终疗效和安全性.
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