环状电路与海洛因使用的升级和纳洛诱导的海洛因自我管理的增加有关
M J Scarlata1, R J Keeley1, S A Carmack2
1Neuroimaging Research Branch, National Institute on Drug Abuse, United States of America.
Addiction neuroscience
|June 16, 2023
概括
阿片类药物使用障碍 (OUD) 涉及强迫性寻找和使用阿片类药物. 在老鼠的大脑成像显示,与海洛因摄入升级和戒断反应相关的环状皮质 (Cg) 中明显的神经电路变化.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 神经成像是一种神经成像.
背景情况:
- 阿片类药物使用障碍 (OUD) 具有强迫性阿片类药物寻找,失去控制和戒断期间的负面情绪状态的特征.
- 了解OUD的神经基础对于制定有效的预防和治疗策略至关重要.
研究的目的:
- 在大鼠模型中,研究与海洛因自我管理 (SA) 的升级和纳洛沉导致的SA增加相关的明显脑电路变化.
- 使用功能磁共振成像 (fMRI) 识别阿片类成不同方面特定的神经相关物.
主要方法:
- 使用功能磁共振成像 (fMRI) 分析休息状态功能连接 (rsFC) 和低频波动 (ALFF) 幅度在OUD的老鼠模型中.
- 研究了与海洛因SA升级和对抗剂诱导的SA增加有关的脑电路的变化,这些变化集中在带状皮层 (Cg).
主要成果:
- 海洛因SA的升级与Cg和背条体之间的rsFC负相关.
- 纳洛注射后增加的海洛因SA与Cg与扩展的杏仁体/下丘脑之间的增强连接相关.
- 纳洛诱导的SA增加与Cg内的ALFF积极相关,表明自发神经元活动发生变化.
结论:
- 阿片类药物使用障碍的不同方面,如升级和戒断诱导的渴望,由涉及环状皮质的独特神经回路进行调解.
- 这些发现增强了我们对OUD神经生物学的理解,并可能为药物成的有针对性的治疗干预提供信息.
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