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相关概念视频

Olfaction01:25

Olfaction

44.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.5K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.8K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.8K

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相关实验视频

Updated: Jul 26, 2025

Simple and Computer-assisted Olfactory Testing for Mice
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Simple and Computer-assisted Olfactory Testing for Mice

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嗅觉皮层中性别差异 衰老中的神经元损失

Majed M Alotaibi1,2, Matteo De Marco3, Annalena Venneri3,4

  • 1Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield, United Kingdom.

Frontiers in human neuroscience
|June 16, 2023
PubMed
概括

大脑衰老会影响嗅觉皮层的体积. 这一区域的神经元损失在女性中比男性更早地开始,这表明神经退行性疾病的潜在早期检测.

关键词:
老化的老化 衰老的老化缩性缩 (英语:Atrophy atrophy) 是一种损伤.神经成像是一种神经成像.发生神经元损失.嗅觉皮层的嗅觉皮层.在性爱中,性爱是性爱.

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A Free-breathing fMRI Method to Study Human Olfactory Function
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Olfactory Assays for Mouse Models of Neurodegenerative Disease

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相关实验视频

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A Free-breathing fMRI Method to Study Human Olfactory Function
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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 放射学 放射学是一门学科.

背景情况:

  • 衰老是神经退行性疾病 (如阿尔茨海默氏症) 的重要因素.
  • 嗅觉功能障碍可能是老年人神经退行症的早期指标.
  • 研究嗅觉大脑区域可能有助于早期发现疾病并预防嗅觉丧失的后果.

研究的目的:

  • 确定年龄和性别如何影响认知健康个体的嗅觉皮层体积.

主要方法:

  • 认知健康的参与者被分为三个年龄组:年轻人 (20-35岁),中年人 (36-65岁) 和老年人 (66-85岁).
  • 使用SPM12软件分析了T1加权的MRI扫描 (1.5T).
  • 用光滑的MRI图像来量化嗅觉皮层的体积.

主要成果:

  • 在嗅觉皮层体积中观察到与年龄相关的显著差异 (p ≤ 0.0001).
  • 女性在嗅觉皮层中表现出较早的神经元损失的发病,从他们的第四个十年开始.
  • 男性在晚年生活中表现出更大的嗅觉皮层神经元损失.

结论:

  • 与年龄相关的嗅觉皮层体积减少在女性中比男性更早开始.
  • 在老年人群中,嗅觉大脑区域体积的变化可能是增加神经退行性疾病风险的潜在指标.