在结核性硬化综合体中理解语音和语言
Tanjala T Gipson1, D Kimbrough Oller2, Daniel S Messinger3,4,5,6
1Department of Pediatrics, Le Bonheur Children's Hospital, The Boling Center for Developmental Disabilities, University of Tennessee Health Science Center, Memphis, TN, United States.
Frontiers in human neuroscience
|June 16, 2023
概括
结核性硬化综合体 (TSC) 和自闭症谱系障碍 (ASD) 分享语言延迟. 像喋喋不休和声音轮流这样的早期前体对于理解和治疗ASD的TSC的言语和语言困难至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 结核性硬化综合体 (TSC) 是一种神经皮肤疾病,与自闭症谱系障碍 (ASD) 的共同发生率很高,影响约50%的个人.
- TSC是综合症ASD的重要原因,使得对这一群体的语言发展的研究对于ASD研究的更广泛影响至关重要.
- 虽然多达70%的TSC患者报告说有语言困难,但目前的研究往往依赖于总结分数,缺乏详细的机制理解.
研究的目的:
- 审查有关结核性硬化综合体 (TSC) 患者语言发展的当前知识,以及其与自闭症谱系障碍 (ASD) 的关系.
- 确定语言发育的早期前体,这些前体在TSC和ASD中都存在延迟,指导未来的研究方向.
- 探索早期识别和治疗TSC语言困难的潜在策略.
主要方法:
- 关于TSC和ASD语音和语言发展的现有文献的小综述.
- 早期语言前体的分析,包括正规的喋喋不休,发言力,声音轮流,共享注意力和快速映射.
- 综合发现,以确定TSC,ASD和有ASD的综合性TSC之间的语言轨迹的共同点和差异.
主要成果:
- 语言出现的关键预测因素 - - 规范性语和发言能力 - - 在TSC的婴儿中延迟,反映了在异形ASD中观察到的延迟.
- 该审查确定了声音轮流,共享注意力和快速映射作为其他关键的早期语言前体,需要在TSC进行调查.
- 了解这些前体可以揭示TSC语音和语言延迟背后的机制及其与ASD的联系.
结论:
- 在TSC中语言发育受到显著影响,早期的前体,如喋喋不休和易言易语,表现出与ASD类似的延迟.
- 调查前体,如语音轮流,共享注意力和快速映射,对于全面了解TSC的语音和语言发展至关重要.
- 这项研究旨在改进早期检测和干预策略,以对患有TSC,有或没有自闭症的个体进行普遍的语言困难.
相关概念视频
Language and Cognition
378
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
378
Autism Spectrum Disorder
166
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
166
Higher Mental Functions of the Brain: Language
937
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
937
Language Development
404
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
404
Learning Disabilities
221
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
Dyslexia
Dyslexia is a...
221
Microtubules in Signaling
1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K


