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在没有的情况下的神经调节素1/ERbB4的改变:对TRPV1表达的调节作用

Farideh Talebi^1,2, Samira Ghorbani², Leila Alizadeh²

¹Immunoregulation Research Center, Shahed University, Tehran, Iran.

Basic and clinical neuroscience

|June 16, 2023

概括

神经调节蛋白1 (NRG1) / ERbB4 和 TRPV1 途径与缺席有关. 它们的表达模式是相关的,这表明ERbB4调节了发作的TRPV1.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
的研究研究.

背景情况:

神经调节蛋白1 (NRG1) /ERbB4信号通路与神经系统疾病有关.
瞬态受体潜在化物1 (TRPV1) 通道在感官信号传递中发挥作用,并与神经疾病有关.

研究的目的:

研究在缺席的发展过程中NRG1/ERbB4通路和TRPV1信号的变化.
利用遗传动物模型探索这些途径在缺席病理生理学的潜在作用.

主要方法:

NRG1,ERbB4和TRPV1的蛋白质水平在雄性WAG/Rij (模型) 和Wistar大鼠的体感皮质和海马体内测量.
动物在2个月和6个月大时进行了研究,以评估发育变化.

主要成果:

在6个月大的WAG/Rij大鼠中,皮层NRG1和ERbB4水平较Wistar大鼠低.
与对照组相比,在2个月和6个月大的WAG/Rij大鼠中,TRPV1水平降低了.
在WAG/Rij大鼠中,海马NRG1水平随着年龄的增长而下降,而ErbB4和TRPV1则表现出年龄相关的变化,NRG1/ERbB4和TRPV1表达之间存在很高的相关性.

结论:

NRG1/ERbB4通路和TRPV1可能参与缺席的发病.
类似的表达模式表明ERbB4在的背景下对TRPV1表达的调节作用.

关键词:

大脑皮层大脑皮层是一种病.这是ErbB-4的原型.神经监管素是一种神经监管素.接收器接收器接收器暂时接收器潜在道潜在道

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