结核性和非结核性多流液之间的区别使用10×腺氨酸脱胺酶/乳酸脱酶的多液比率
Yan Li1, Zhujun Chen2, Pan Yang2
1Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Journal of thoracic disease
|June 16, 2023
概括
在多流 (PE) 中,腺氨酸脱氨酶 (ADA) 与乳酸脱酶 (LDH) 的比率有效地区分结核PE (TBPE) 与非TBPE. 这10倍的ADA/LDH指数为TBPE提供了更好的诊断准确性.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 生物化学 生物化学
背景情况:
- 腺氨酸脱氨酶 (ADA) 是结核性肺溢液 (TBPE) 的标记物.
- 由于细胞计数的变化,仅ADA在区分TBPE方面存在局限性.
- 假阳性和假阴性限制了ADA在多叶流液 (PE) 的诊断精度.
研究的目的:
- 探索ADA/LDH比率在区分TBPE与非TBPE方面的临床价值.
- 为了评估TBPE的10x ADA/LDH指数的诊断准确性.
主要方法:
- 从2018年1月到2021年12月,对382名PE患者进行了回顾性分析.
- 在TBPE和非TBPE组中测量了ADA,LDH,并计算了10倍的ADA/LDH水平.
- 使用接收器操作曲线评估灵敏度,特异性和诊断准确性.
主要成果:
- 在TBPE患者中,10倍的ADA/LDH水平显著更高.
- 在TBPE中观察到ADA和LDH水平之间存在正相关性.
- 在ADA水平>20U/L时,10x的ADA/LDH显示出高诊断性能 (灵敏度0.95,特异性0.94).
结论:
- 10倍的ADA/LDH指数是区分TBPE与非TBPE的有价值工具.
- 这个诊断指数可以帮助指导PE管理的临床决策.
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