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Updated: Jul 26, 2025

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Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
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口服利芬素干扰了肺结核患者的尿液测量棒测试
Fei Wang1, Lihui Zhao1, Wei Du1
1Department of Laboratory Medicine, Wuhan Pulmonary Hospital, Wuhan, China.
Journal of thoracic disease
|June 16, 2023
概括
利芬素及其代谢物干扰了结核病患者的尿液测量棒测试. 在利芬西因服用12-24小时后收集尿液可以防止这些干扰.
科学领域:
- 临床化学 临床化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 利芬素 (RMP) 和其代谢物脱乙利芬素 (dRMP) 用于治疗结核病 (TB).
- 这些化合物可以干扰标准尿液滴棒测试 (UDTs).
研究的目的:
- 调查RMP和dRMP对UDT的影响,使用两个不同的测量棒品牌.
- 为了确定引起干扰的RMP和dRMP的度范围.
主要方法:
- 尿液测色仪用于测量RMP度在2-6和12-24小时后给药.
- 在体外干扰测定和确认测试是在Arkray的Aution Sticks 10EA和GIMA的Combi-Screen 11SYS Plus上进行的.
主要成果:
- 在两种测量棒类型中观察到蛋白质,白细胞化酶,类和酸盐分析物的显著干扰.
- 干扰水平随RMP度而变化,根据分析物和测量棒,从125μg/mL到500μg/mL不等.
结论:
- 在不同程度上,RMP和dRMP会干扰UDT.
- 在体外测试不是完全可靠的替代确认性测试.
- 在RMP摄入后12-24小时采样尿液可以最大限度地减少干扰,提高测试准确性.
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