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慢性阻塞性肺病肺组织向代谢的变化
Yi Feng1, Meiqin Xie1, Qi Liu1
1Department of Pulmonary and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of thoracic disease
|June 16, 2023
概括
代谢分析显示慢性阻塞性肺病 (COPD) 患者和小鼠模型中氨基酸和碳水化合物代谢发生变化. 这些变化与衰老,亡,氧化应激和炎症有关,这表明COPD病变的关键途径.
科学领域:
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
- 肺部医学 肺部医学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个普遍且日益严重的全球健康问题.
- 人类患者和动物模型之间有病理和生理相似之处.
- 了解新陈代谢变化对于阐明COPD的发病过程至关重要.
研究的目的:
- 研究涉及COPD发展的代谢途径.
- 为了确定与COPD相关的潜在生物标志物.
- 将人类COPD的代谢变化与小鼠模型进行比较.
主要方法:
- 针对性代谢学 (HM350) 在人类和小鼠的肺组织上进行.
- 多变量分析和途径分析利用了基因和基因组的京都百科全书 (KEGG) 数据库.
- 在两种物种中进行了COPD和对照组之间的比较分析.
主要成果:
- 在人类的COPD和小鼠模型中观察到氨基酸,碳水化合物和卡尼丁代谢的显著变化.
- 脂质代谢的变化是针对COPD小鼠模型的特异性.
- 凯格路径分析将改变的代谢物与衰老,亡,氧化应激和炎症联系起来.
结论:
- 在人类COPD患者和暴露于香烟烟雾的小鼠之间,代谢物表达的变化是一致的.
- 在代谢产物和途径中发现了特定物种的差异.
- 氨基酸代谢,能量生产和潜在的脂质代谢的失调与COPD的发病有很强的关联.
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