肥胖和肺癌 - - 一个叙事性综述
Yeshwanth Vedire1, Sukumar Kalvapudi1, Sai Yendamuri1,2
1Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Journal of thoracic disease
|June 16, 2023
概括
肺癌中的"肥胖悖论"可能源于使用体重指数 (BMI) 作为不良的肥胖度量. 中部肥胖,而不是BMI,与更高的肺癌风险和更糟糕的结果有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肥胖和肺癌之间的关系是复杂的,受到年龄,性别和种族等因素的影响.
- 增加的体重指数 (BMI) 矛盾地与肺癌发病率和死亡率的降低有关,被称为"肥胖悖论".
- 肥胖悖论的潜在解释包括BMI在测量身体组成方面的局限性,吸烟混以及反向因果关系.
研究的目的:
- 澄清各种肥胖指标与肺癌风险之间的关联.
- 阐明不同衡量脂肪和肺癌预后之间的关系.
- 解决有关肥胖和肺癌的现有文献中相互矛盾的结论.
主要方法:
- 在PubMed上进行了一项文献搜索,搜索了2018年至2022年期间以英语出版的研究.
- 确定了69个相关出版物,并对其全文进行了分析.
- 审查的重点是研究肥胖指标,肺癌风险和预后的研究.
主要成果:
- 更高的BMI与较低的肺癌发病率和更好的预后有关,即使在调整吸烟和减肥后也是如此.
- 体重指数较高的人对免疫疗法等治疗反应更好.
- 这些关联因年龄,性别和种族而异,突出显示了BMI在捕捉身体成分方面的局限性.
结论:
- 肥胖悖论可能是使用BMI的工件,BMI不充分反映身体组成.
- 衡量中心肥胖的指标更容易表明不良影响,并且与肺癌发病率和预后更好地相关.
- 需要使用标准化人体测量和成像指标进行进一步的研究,以准确评估肥胖对肺癌的影响.
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