活跃肺结核患者的营养状况和活跃肺结核的新营养风险查模型:中国的一项全国性,多中心,横截面研究
Wei Chen1, Qin Ding1, Sheng-Kang Zhang2
1Nutritional Department, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Journal of thoracic disease
|June 16, 2023
概括
结核病患者经常遭受严重的营养不良. 针对活跃结核病患者开发的新查模型在识别营养风险方面表现出高准确性,为这一群体提供了量身定制的方法.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 结核病 (TB) 是一个重大的全球健康挑战,经常与营养不良有关.
- 有限的研究存在于查营养不良,特别是在结核病患者队列内.
- 这项研究解决了评估营养状况的需要,并开发了一种专门的活跃结核病查模型.
研究的目的:
- 评估活跃结核病患者的营养状况.
- 为结核病患者构建一个针对结核病患者优化的新型营养查模型.
- 确定与结核病营养不良相关的独立风险因素.
主要方法:
- 一个大规模的,回顾性,多中心的横截面研究在中国 (2020-2021).
- 使用2002年营养风险查 (NRS 2002) 和全球营养不良领导倡议 (GLIM) 标准对活跃肺结核 (PTB) 患者的评估.
- 包括单变量和多变量方法在内的统计分析,以确定风险因素并开发预测模型.
主要成果:
- 分析了超过14,900名PTB患者,显示高营养不良率 (NRS 2002年55.86%,GLIM 42.70%).
- 在NRS 2002和GLIM标准之间观察到显著的不一致性 (24.77%).
- 确定了11个营养不良的独立风险因素,包括低BMI,老年状况以及DM和HIV等并发症.
结论:
- 活跃的结核病患者表现出严重的营养不良,需要有针对性的查.
- 新开发的查模型显示了高的诊断准确性 (97.6%的灵敏度,93.1%的特异性).
- 这种量身定制的模型推用于PTB患者,因为它对结核病特定特征的相关性有所改善.
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