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-酸结合物与angiopep-2用于中子捕获疗法

Jing Xiang¹, Lin Ma², Jianfei Tong^3,4

¹Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, China.

Frontiers in medicine

|June 16, 2023

概括

新型-联体 (ANG-B) 在中子捕获疗法 (BNCT) 中表现出增强的疗效,通过增加癌细胞中的吸收,并与标准药物相比显著改善瘤破坏.

科学领域:

在瘤学瘤学.
放射疗法是一种放射治疗.
生物结合化学生物结合化学

背景情况:

中子捕获疗法 (BNCT) 通过核反应提供向的癌细胞破坏.
开发有效的输送剂对于提高BNCT的疗效和最大限度地减少目标外毒性至关重要.

研究的目的:

合成和评估新型-联体 (ANG-B) 结合 angiopep-2 用于向在癌症中的输送.
为了在体外和体内比较ANG-B与氨酸 (BPA) 的临床前疗效.

主要方法:

固相合成被用于制造-联体.
使用ICP-AES在癌细胞系和小鼠质瘤模型中量化的度.
进行了体外克隆性细胞死亡测定和体内PET/CT成像.

主要成果:

与对照组相比,ANG-B显著增加了癌细胞中的吸收.
在体外BNCT与ANG-B导致86.5%的细胞死亡,超过BPA的73.3%.
在体内研究表明,ANG-B治疗导致质瘤模型中的平均瘤缩率为62.9%,与BPA治疗的23.0%相比.

结论:

作为BNCT的输送剂,ANG-B表现出卓越的性能.
ANG-B 具有较低的细胞毒性和高的瘤对血液比率,这表明临床翻译的潜力.
这些发现支持ANG-B在癌症治疗中推进BNCT的承诺.

关键词:

中子捕获疗法 (BNCT) 是一种安吉奥佩普-2 的使用.二元辐射疗法二元辐射疗法 - 酸联合体的 - 酸联合体癌症医学癌症医学癌症医学

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