婚姻状况对非小细胞肺癌患者的独立预后影响:基于人口的研究
Dechang Zhao1,2, Rusi Zhang1,2, Longjun Yang1,2
1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Frontiers in medicine
|June 16, 2023
概括
婚姻状况显著影响非小细胞肺癌 (NSCLC) 患者的生存率. 未婚的NSCLC患者面临更糟糕的整体生存率 (OS) 和癌症特异性生存率 (CSS),强调需要增加支持.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 婚姻状况是众所周知的各种癌症的预后因素.
- 非小细胞肺癌 (NSCLC) 婚姻状况的预后价值仍然存在争议.
研究的目的:
- 研究非小细胞肺癌 (NSCLC) 患者的婚姻状况和生存结果之间的关联.
- 开发基于临床病理学因素,包括婚姻状况的NSCLC患者生存率的预测模型.
主要方法:
- 利用了监测,流行病学和最终结果 (SEER) 数据库,用于2010-2016年间诊断的NSCLC患者.
- 雇员倾向分数匹配 (PSM) 以平衡已婚和未婚群体之间的基线特征.
- 进行了考克斯回归,构建了名图,并进行了决策曲线分析 (DCA) 来评估预后因素和预测准确性.
主要成果:
- 与未婚患者相比,已婚NSCLC患者的整体存活率 (OS) 和癌症特异性存活率 (CSS) 显著改善.
- 单身患者,在未婚组中,生存结果最差.
- 开发的结合婚姻状况的诺姆图表显示了对1年,3年和5年生存概率的良好预测准确性.
结论:
- 未婚状态是NSCLC患者独立的负预后因素.
- 未婚NSCLC患者需要更密切的监测和增强的社会/家庭支持,以潜在地改善坚持和生存.
- 开发的诺姆图可以帮助预测存活率,并指导NSCLC患者的临床管理.
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