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肥胖与移植患者的延迟移植功能有关:对分析
Bree Shi1,2, Tracey Ying1,2,3, Josephine Xu2,4,5
1Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia.
概括
肥胖增加了移植接受者的风险,导致更高的移植功能延迟,移植失败和死亡率. 解决肥胖症对于改善长期患者和移植移植后的移植生存至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 公共卫生 公共卫生
背景情况:
- 肥胖是移植候选人的日益关注的问题.
- 之前对肥胖患者移植后结果的研究已经产生了相互矛盾的结果,可能是由于未解决的与捐赠者相关的混因素.
研究的目的:
- 为了比较肥胖和非肥胖脏移植接受者之间的移植和患者存活率.
- 通过分析配对脏捐赠来控制捐赠者的特征.
主要方法:
- 使用的ANZDATA 2000年至2020年的注册表数据.
- 选择的移植对,其中一个脏送给肥胖的接受者,另一个送给非肥胖的接受者.
- 采用多变量模型来比较延迟移植功能 (DGF),移植失败和死亡.
主要成果:
- 分析了1522个移植对.
- 肥胖与DGF风险显著增加有关 (aRR = 1.26).
- 肥胖的接受者面临死亡审查的移植失败 (aHR = 1.25) 和功能死亡 (aHR = 1.32) 的更高风险.
- 与非肥胖患者相比,肥胖患者的长期存活率更差 (10年后71%,15年后56%) 和非肥胖患者的长期存活率更差 (10年后77%,15年后63%).
结论:
- 肥胖与脏移植的较差结果有关,包括增加DGF,移植失败和死亡率.
- 对捐赠因素的控制证实了接受者肥胖的负面影响.
- 管理肥胖症代表着一个重要的未满足的临床需求,以优化脏移植的成功.
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