影响脑下垂体功能障碍的特征和因素,在患有脑瘤的患者中
Ying Guo1, Lili Pei1, Yuzheng Li1
1Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|June 16, 2023
概括
喉瘤的手术显著恶化下丘脑下垂体功能障碍 (HPD) 在两个 adamantinomatous (ACP) 和 papillary (PCP) 类型. 老年,瘤复发和ACP类型是手术后HPD恶化的关键风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 膜瘤是一种良性细胞区域瘤,由于瘤质量效应,手术或放射治疗,可以导致严重的下丘脑-垂体功能障碍 (HPD).
- 高血压严重影响患者的长期生活质量.
- 对于患者管理来说,了解阿达曼蒂诺马图斯瘤 (ACP) 和乳头瘤 (PCP) 的HPD特征至关重要.
研究的目的:
- 在ACP和PCP患者中研究HPD的特征.
- 为了确定导致手术后HPD恶化的因素.
- 为了比较ACP和PCP亚型之间的HPD差异.
主要方法:
- 一个单一中心的回顾性研究包括742名喉瘤患者.
- 在手术前后评估神经内分泌功能.
- 分析了ACP和PCP组之间的差异,并确定了HPD恶化的危险因素.
主要成果:
- 在手术前,与ACP患者相比,PCP患者的糖尿病无味症和高血糖血症的发病率更高,上皮层功能低下的发病率更低.
- 经过手术后,ACP和PCP组都显示了腺细胞低功能的增加,无味糖尿病和下丘脑肥胖症,而ACP组的增加更大.
- 发病时的年龄较大,瘤复发/进展以及ACP类型被确定为术后HPD恶化的危险因素.
结论:
- 手术治疗在ACP和PCP中显著加剧了HPD,但每个亚型都有不同的特征和风险因素.
- 确定这些特定因素对于优化手术结果和长期患者护理至关重要.
- 进一步的研究可能将重点放在针对不同类型的喉瘤亚型的量身定制的管理策略上,以减轻HPD.
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