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新辅助化疗后的囊切除术:一个单一中心的经验

R B Nerli^1,2, Shridhar C Ghagane^1,2, Rangrez Shadab¹

¹Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-To-Be-University), JNMC Campus, Nehru Nagar, Belagavi, 590010 India.

Indian journal of surgical oncology

|June 16, 2023

概括

在急性囊切除术之前的新辅助化疗为肌肉侵入性膀癌提供了安全有效的治疗方法. 这种方法在改善局部晚期疾病患者的治疗结果方面表现有前途.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医学瘤学医学瘤学

背景情况:

肌肉侵入性膀癌 (MIBC) 仅仅在囊切除术后经常发生转移.
基于西斯普拉丁的化疗在治疗膀癌症方面显示出有效性.
囊切除术前的新辅助化疗正在研究晚期膀癌.

研究的目的:

追溯评估新辅助化疗的安全性和有效性,然后在MIBC患者中进行激进囊切除术.

主要方法:

在2005年至2019年期间,对72名MIBC患者进行了新辅助化疗和激进囊切除术的回顾性审查.
分析患者人口统计,化学疗法完成率和生存结果.
评估治疗安全性和监测化疗引起的毒性.

主要成果:

患者的中位年龄为59.8岁 (男性与女性的比例为5:1).
50%的患者在随访期间死亡;平均存活时间为84.85个月,中位数生存时间为91.0个月.
新辅助性MVAC化疗在具有充分功能的患者中通常是安全和有效的.

结论:

新辅助化疗,特别是MVAC,建议适合接受激进囊切除术的MIBC患者使用.
仔细监测化疗毒性对于患者安全至关重要.
这种方法可以成为治疗局部晚期膀癌的宝贵组成部分.

关键词:

药物不良反应药物不良反应膀癌是一种癌症.新辅助化学疗法新辅助化学疗法进行激进的囊切除术.

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