皮埃佐1通道调解了伪孕大鼠子宫动脉的血管松

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Olufunke O Arishe¹, Jaine McKenzie², Vanessa Dela Justina³

¹Department of Physiology, University of Tennessee Health Sciences Center, Memphis, TN, United States.

Frontiers in physiology

|June 16, 2023

概括

机械敏感的Piezo1通道在怀孕期间有助于子宫动脉扩张. 激活Piezo1通道会导致依赖氧化的放松,特别是在怀孕的老鼠中.

科学领域:

身体生理学身体生理学
血管生物学血管生物学
生殖科学生殖科学

背景情况:

怀孕涉及显著的心血管适应,包括增加子宫动脉血流.
子宫动脉血管扩张对于满足胎儿代谢需求至关重要,但其机制尚未完全理解.
皮埃佐1机械敏感通道参与血管重塑,存在于动脉细胞中.

研究的目的:

调查机器敏感Piezo1通道在妊娠期间子宫动脉 (UA) 血管扩张中的作用.
测试Piezo1通道有助于怀孕引起的UA扩张的假设.

主要方法:

实验使用来自伪怀孕和处女Sprague Dawley大鼠的隔离子宫动脉 (UA) 和中腔阻力动脉 (MRA).
用Yoda 1在一个安装在线丝肌谱仪中的隔离容器中进行了Piezo1通道的化学激活.
使用抑制剂和无溶液研究了约达1诱导放松的机制.

主要成果:

与处女大鼠相比,Yoda 1诱导了假孕大鼠在UA中的更大的度依赖放松.
在两组之间的中腔阻力动脉 (MRA) 中,没有观察到Yoda 1响应的显著差异.
在这两种血管床上,Yoda 1的放松部分依赖于氧化.

结论:

机械敏感的Piezo1通道介导子宫动脉中依赖氧化的放松.
皮埃佐1通道似乎在怀孕期间观察到的子宫动脉加强血管扩张中发挥作用.

关键词:

一个Piezo1频道.它们的内皮质 (endothelium).机械传导机械传导怀孕怀孕怀孕怀孕怀孕血管放松血管放松

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