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针对 urachal carcinoma 的向治疗和免疫治疗的进展和前景

Yang Zheng^1,2, Heling Peng³, Xu Hu⁴

¹School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in pharmacology

|June 16, 2023

概括

口腔癌 (UrC) 与结直肠癌 (CRC) 有分子相似之处,这表明像EGFR抑制剂这样的向疗法可能是有效的. 生物标志物,如MMR状态和PD-L1表达,对于晚期UrC的免疫治疗至关重要.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

口腔癌 (UrC) 是一种罕见的,具有攻击性的恶性瘤,对于晚期的治疗选择有限.
化疗疗效率受到限制,需要探索向和免疫疗法.
了解UrC的分子特征对于制定个性化治疗策略至关重要.

研究的目的:

系统地审查UrC的分子概况.
为了确定个性化治疗的潜在分子点.
在UrC中探索免疫检查点抑制剂治疗的生物标志物.

主要方法:

在PubMed,EMBASE和Web of Science数据库中进行了系统的文献搜索.
搜索集中在UrC的向治疗和免疫治疗,从开始到2023年2月.
分析包括28篇符合条件的文章和420个UrC病例,以确定基因突变.

主要成果:

最常见的是TP53突变 (70%),其次是KRAS (28.3%),MYC (20.3%),SMAD4 (18.2%) 和GNAS (18%).
与结直肠癌相比,UrC分子模式显示了相似之处和差异.
针对EGFR的治疗显示出在UrC治疗疗效的潜力.

结论:

UrC的分子形状与CRC有相似之处,表明有针对性治疗的潜力.
EGFR抑制剂和免疫检查点抑制剂 (基于MMR状态和PD-L1) 是有前途的治疗途径.
针对性药物和免疫治疗的组合疗法可以提高UrC患者的治疗结果.

关键词:

欧洲农业基金会 (EGFR) 是一个基金.生物标志物生物标志物免疫疗法免疫疗法有针对性的治疗.尿道癌 (Urachal Carcinoma) 是一种癌症.

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