相关实验视频
Updated: Jul 26, 2025
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
6.5K
在新生儿中,基于无脂肪质量的健美素剂量方案是否比全身体重更好?
Kannan Sridharan1, Muna Al Jufairi2,3, Eman Al Ansari2
1Department of Pharmacology and Therapeutics College of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain.
Pediatric investigation
|June 16, 2023
概括
在重症新生儿中优化 جنت米辛剂量至关重要. 没有脂肪的大量剂量显示出实现治疗性 gentamicin 度的希望,改善新生儿的治疗结果.
科学领域:
- 新生儿药理学 新生儿药理学
- 药理动力学 药理动力学
- 儿科重症监护 儿科重症监护 儿科重症监护
背景情况:
- 新生儿体液动力学和脏成熟影响药物度.
- 由于生理学变异,在新生儿中使用珍塔素剂量需要仔细考虑.
研究的目的:
- 为了预测重症新生儿的峰值和低温 gentamicin 度.
- 根据无脂肪质量对比传统的基于体重的方法来评估根他米辛的剂量.
主要方法:
- 招募89名患病危急的新生儿接受 gentamicin 治疗.
- 使用皮层厚度估计脂肪质量.
- 使用全身重量和无脂肪质量为基础的剂量对 gentamicin 血峰值度 (Cmax) 的比较.
主要成果:
- 治疗次的Cmax发生在32.6%和22.5%的新生儿当前剂量方案.
- 产前新生儿的脂肪量明显高于产后新生儿.
- 在所有新生儿中,基于无脂肪质量的剂量在第二剂后实现了治疗性Cmax (>12μg/ml).
结论:
- 没有脂肪的大量剂量可能是一个优越的策略,以优化新生儿的 جنت米辛治疗.
- 为不同妊娠年龄组提供调整的剂量建议,以确保治疗疗效.
相关概念视频
01:21Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
01:11Renal Failure: Dose Adjustments
127
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
127