冠状动脉微血管功能障碍妇女的自身免疫性风湿性疾病:来自妇女缺血综合征评估-冠状动脉功能障碍 (WISE-CVD) 项目的报告
Melanie T Chen1, Joseph Chang1, Ashley S Manchanda1
1Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, United States.
Frontiers in cardiovascular medicine
|June 16, 2023
概括
患有自身免疫性类风湿性疾病 (ARD) 和冠状动脉微血管功能障碍 (CMD) 的女性的功能状况和心肌 perfusion 情况更差. 这凸显了对ARD进一步研究的需要.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 自身免疫性类风湿性疾病 (ARDs) 与冠状动脉微血管功能障碍 (CMD) 有关.
- 在患有缺血并没有阻塞性动脉 (INOCA) 的女性中,ARDs对CMD的影响尚不清楚.
- 这项研究调查了INOCA的女性ARD病史和CMD结局之间的关系.
研究的目的:
- 为了确定CMD和ARD病史的妇女是否增加了胸痛,功能限制和心肌输液妥协.
- 为了比较CMD妇女的结果,按ARD病史的存在或不存在分层.
主要方法:
- 利用了来自女性缺血综合征评估-冠状动脉血管功能障碍 (WISE-CVD) 项目的数据.
- 包括INOCA和通过侵入性冠状动脉功能测试确认的CMD的妇女.
- 评估了西雅图心痛问卷 (SAQ),杜克活动状态指数 (DASI) 和心磁共振心肌输液储备指数 (MPRI).
主要成果:
- 在207名患有CMD的女性中,有19名 (9%) 具有ARD病史.
- 患有ARD的女性年轻,DASI得分 (功能状态) 较低,MPRI (心肌输液储备) 较低.
- 在患有ARD的女性中,观察到增加夜间和压力诱发性心痛的趋势.
结论:
- 患有CMD和ARD史的女性表现出较差的功能状态和心肌输液储备.
- 胸痛症状和侵袭性冠状动脉功能在各组之间没有显著差异.
- 需要进行进一步的研究,以阐明ARD和INOCA的妇女中CMD的机制.
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