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父母报告的儿童食欲减轻了儿童遗传肥胖风险和父母养习惯之间的关系
Elena Jansen1, Marcus Naymik2, Gita Thapaliya1
1Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Frontiers in nutrition
|June 16, 2023
概括
父母可以根据孩子的遗传肥胖风险和食欲调整养习惯. 具体来说,父母限制了高遗传风险和高食物反应的儿童的食物摄入量,这表明儿童肥胖的基因环境相关性.
科学领域:
- 儿科肥胖症研究的研究.
- 行为遗传学行为遗传学
- 基因与环境的相互作用
背景情况:
- 父母的养习惯与孩子的体重有关.
- 这些关联可能反映了父母对孩子对肥胖的遗传倾向的反应 (基因环境相关性).
- 这项研究探讨了食物育儿中的基因环境相关性以及儿童食欲的作用.
研究的目的:
- 调查儿童遗传肥胖风险和父母的养做法之间的基因环境相关性.
- 检查儿童食欲在这些关系中的适度作用.
主要方法:
- 在RESONANCE儿科队列研究中利用了197个亲子对称的数据.
- 使用成人GWAS数据评估儿童的体重指数 (BMI) 多基因风险评分 (PRS).
- 收集了家长报告的关于养习惯和儿童饮食行为的数据.
主要成果:
- 两种养习惯与儿童BMI PRS有关:限制体重控制 (积极关联) 和关于营养的教学 (负面关联).
- 当孩子具有高遗传肥胖风险和中度/高食物反应时,父母对体重控制的食物摄入的限制更有可能发生.
结论:
- 父母的养习惯可能适应孩子对体重的遗传敏感性.
- 限制食物的做法似乎受到父母对孩子食欲的看法的影响.
- 需要对儿童体重,食欲和从婴儿期开始的育儿进行进一步的纵向研究.
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