呼吸道微生物群在喘中的作用
Christina D Campbell1, Margaret Gleeson1, Imran Sulaiman1,2
1Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Frontiers in allergy
|June 16, 2023
概括
人类微生物组会影响喘的发展和严重程度. 生物疗法可以通过平衡气道微生物群和减少炎症来改善喘.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 喘是一种普遍存在的呼吸道疾病,人类微生物群在其发病过程中发挥着关键作用.
- 呼吸道微生物组的组成根据喘表型,内型和严重程度不同.
- 目前的喘疗法直接影响呼吸道微生物群.
研究的目的:
- 研究生物疗法在调节喘中呼吸道微生物群中的作用.
- 探索微生物组改变作为控制喘的治疗策略的潜力.
主要方法:
- 分析生物疗法对耐火性2型高喘患者呼吸道微生物群的影响.
- 评估生物治疗后呼吸道炎症的变化和临床结果.
主要成果:
- 生物疗法虽然针对呼吸道炎症,但似乎也改变了呼吸道微生物群.
- 这些变化可能会导致更平衡的呼吸道微环境.
- 一个下调的炎症级联和改善的临床结果表明,生物疗法,微生物群和宿主免疫力学之间存在联系.
结论:
- 生物疗法代表了管理喘恶化和改善疾病控制的潜在治疗目标.
- 改变微生物组与宿主免疫系统的动态是喘治疗的一个有希望的途径.
- 对喘疗法对微生物组调节效应的进一步研究是有必要的.
更多相关视频
08:58Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
43.1K
06:43Studying Microbial Communities In Vivo: A Model of Host-mediated Interaction Between Candida Albicans and Pseudomonas Aeruginosa in the Airways
Published on: January 13, 2016
8.9K
相关概念视频
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma-I: Introduction
2.7K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.7K
Asthma: Pathogenesis and Management
461
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
461
Overview of Respiratory System
4.4K
The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
What is the Respiratory System?
The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...
What is the Respiratory System?
The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...
4.4K
The Bronchial Tree
3.1K
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
3.1K
Physiological Control of Respiration
2.2K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
2.2K
